(4-bromomethylphenyl)-di-tert-butyl-fluorosilane

Base Information

• Chemical Name: (4-bromomethylphenyl)-di-tert-butyl-fluorosilane
• CAS No.: 1265557-92-3
• Molecular Formula: C₁₅H₂₄BrFSi
• Molecular Weight: 331.343
• Mol file: 1265557-92-3.mol

Synonyms:(4-bromomethylphenyl)-di-tert-butyl-fluorosilane

Chemical Property of (4-bromomethylphenyl)-di-tert-butyl-fluorosilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-bromomethylphenyl)-di-tert-butyl-fluorosilane

There total 4 articles about (4-bromomethylphenyl)-di-tert-butyl-fluorosilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(di-tert-butylfluorosilanyl)benzyl alcohol (1146956-36-6) → (4-bromomethylphenyl)-di-tert-butyl-fluorosilane (1265557-92-3)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.3390/ph14060547

Reference yield:

di-tert-butyl(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane (1146956-34-4) → (4-bromomethylphenyl)-di-tert-butyl-fluorosilane (1265557-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 2 h / 20 °C

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; carbon tetrabromide; triphenylphosphine; In methanol; dichloromethane;

DOI:10.3390/ph14060547

Reference yield:

4-(tert-butyldimethylsiloxymethyl)bromobenzene (87736-74-1) → (4-bromomethylphenyl)-di-tert-butyl-fluorosilane (1265557-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / pentane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 48 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / methanol / 2 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; carbon tetrabromide; tert.-butyl lithium; triphenylphosphine; In methanol; diethyl ether; dichloromethane; pentane;

DOI:10.3390/ph14060547

upstream raw materials:

4-(di-tert-butylfluorosilanyl)benzyl alcohol

4-(tert-butyldimethylsiloxymethyl)bromobenzene

di-tert-butyl(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane

4-bromobenzenemethanol

Downstream raw materials:

N-(4-(di-tert-butylfluorosilyl)benzyl)-2-hydroxy-N,N-dimethylethylammonium bromide

N-(4-(di-tert-butyl[18F]fluorosilyl)benzyl)-2-hydroxy-N,N-dimethylethylammonium bromide