Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester

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Chemical Name:Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester
CAS No.:341544-34-1
Molecular Formula:C₅₂H₈₃NO₆Si
Molecular Weight:846.32
Hs Code.:

Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester

Synonyms:Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester

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Chemical Property of Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester

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Technology Process of Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester

There total 10 articles about Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 341544-37-4
(S)-4-(tert-butyldimethylsilyl)oxy-1-tridecene

: 341544-34-1
Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: O₃ / methanol / -78 °C

1.2: dimethyl sulfide / methanol / 12 h / -78 - 20 °C

2.1: MgSO₄ / diethyl ether / 2 h / 20 °C

3.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 1.5 h / -50 - -40 °C

3.2: diethyl ether / 3 h / -40 - 20 °C

4.1: i-Pr₂NEt / CH₂Cl₂; toluene / 1 h / 20 °C

5.1: pyridine; 4-N,N-9dimethylamino)pyridine / 20 h / 20 °C

With pyridine; titanium(IV) isopropylate; dmap; isopropylmagnesium chloride; magnesium sulfate; ozone; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja004140k

Reference yield:

: 3-(tert-butyl-dimethyl-silanyloxy)-dodecanal

: 341544-34-1
Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: MgSO₄ / diethyl ether / 2 h / 20 °C

2.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 1.5 h / -50 - -40 °C

2.2: diethyl ether / 3 h / -40 - 20 °C

3.1: i-Pr₂NEt / CH₂Cl₂; toluene / 1 h / 20 °C

4.1: pyridine; 4-N,N-9dimethylamino)pyridine / 20 h / 20 °C

With pyridine; titanium(IV) isopropylate; dmap; isopropylmagnesium chloride; magnesium sulfate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja004140k

Reference yield:

: 123493-71-0
(S)-1,2-epoxyundecane

: 341544-34-1
Acetic acid (1R,2R)-2-[(E)-(4S,6S)-4-(benzyl-benzyloxycarbonyl-amino)-6-(tert-butyl-dimethyl-silanyloxy)-pentadec-1-enyloxy]-1,2-dicyclohexyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1.71 g / CuCN / tetrahydrofuran / -78 - 20 °C

2.1: 92 percent / imidazole / dimethylformamide / 4 h / 20 °C

3.1: O₃ / methanol / -78 °C

3.2: dimethyl sulfide / methanol / 12 h / -78 - 20 °C

4.1: MgSO₄ / diethyl ether / 2 h / 20 °C

5.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 1.5 h / -50 - -40 °C

5.2: diethyl ether / 3 h / -40 - 20 °C

6.1: i-Pr₂NEt / CH₂Cl₂; toluene / 1 h / 20 °C

7.1: pyridine; 4-N,N-9dimethylamino)pyridine / 20 h / 20 °C

With pyridine; 1H-imidazole; titanium(IV) isopropylate; dmap; isopropylmagnesium chloride; magnesium sulfate; ozone; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja004140k