Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester

Base Information

Chemical Name:Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester
CAS No.:341544-33-0
Molecular Formula:C₅₀H₈₁NO₅Si
Molecular Weight:804.282
Hs Code.:

Synonyms:Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester

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Chemical Property of Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester

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Technology Process of Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester

There total 9 articles about Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 341544-32-9
(R,R)-1,2-dicyclohexyl-2-hydroxyethyl (1E,4S,6S)-4-N-benzylamino-6-(tert-butyldimethylsilyl)oxypentadec-1-enyl ether

: 341544-33-0
Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 20 ℃; for 1h;
DOI:10.1021/ja004140k

Reference yield:

: 341544-37-4
(S)-4-(tert-butyldimethylsilyl)oxy-1-tridecene

: 341544-33-0
Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: O₃ / methanol / -78 °C

1.2: dimethyl sulfide / methanol / 12 h / -78 - 20 °C

2.1: MgSO₄ / diethyl ether / 2 h / 20 °C

3.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 1.5 h / -50 - -40 °C

3.2: diethyl ether / 3 h / -40 - 20 °C

4.1: i-Pr₂NEt / CH₂Cl₂; toluene / 1 h / 20 °C

With titanium(IV) isopropylate; isopropylmagnesium chloride; magnesium sulfate; ozone; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja004140k

Reference yield:

: 3-(tert-butyl-dimethyl-silanyloxy)-dodecanal

: 341544-33-0
Benzyl-{(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-3-((1R,2R)-1,2-dicyclohexyl-2-hydroxy-ethoxy)-allyl]-dodecyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: MgSO₄ / diethyl ether / 2 h / 20 °C

2.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 1.5 h / -50 - -40 °C

2.2: diethyl ether / 3 h / -40 - 20 °C

3.1: i-Pr₂NEt / CH₂Cl₂; toluene / 1 h / 20 °C

With titanium(IV) isopropylate; isopropylmagnesium chloride; magnesium sulfate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja004140k