(4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole

Base Information

Chemical Name:(4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole
CAS No.:1400638-83-6
Molecular Formula:C₂₆H₂₉N₂OP
Molecular Weight:416.503
Hs Code.:

Synonyms:(4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole

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Chemical Property of (4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole

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Technology Process of (4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole

There total 4 articles about (4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1400638-87-0
(4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-bromophenyl)-4-isopropyloxazole

: 829-85-6
diphenylphosphane

: 1400638-83-6
(4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole

Guidance literature:: diphenylphosphane; With copper(l) iodide; N,N-dimethylethylenediamine; In toluene; at 20 ℃; for 0.333333h; Inert atmosphere; Schlenk technique;

(4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-bromophenyl)-4-isopropyloxazole; With caesium carbonate; In toluene; at 110 ℃; for 6h; Inert atmosphere; Schlenk technique;
DOI:10.1021/om3007163

Reference yield:

: 1035235-21-2
2-bromo-5-(dimethylamino)benzoic acid

: 1400638-83-6
(4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; triethylamine / dichloromethane / 23 h / Inert atmosphere; Reflux

3.1: copper(l) iodide; N,N-dimethylethylenediamine / toluene / 0.33 h / 20 °C / Inert atmosphere; Schlenk technique

3.2: 6 h / 110 °C / Inert atmosphere; Schlenk technique

With copper(l) iodide; 2-chloro-1-methyl-pyridinium iodide; toluene-4-sulfonic acid; N,N-dimethylethylenediamine; triethylamine; In dichloromethane; toluene;
DOI:10.1021/om3007163

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1400638-83-6
(4S)-4,5-dihydro-2-(5′-(dimethylamino)-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; triethylamine / dichloromethane / 23 h / Inert atmosphere; Reflux

3.1: copper(l) iodide; N,N-dimethylethylenediamine / toluene / 0.33 h / 20 °C / Inert atmosphere; Schlenk technique

3.2: 6 h / 110 °C / Inert atmosphere; Schlenk technique

With copper(l) iodide; 2-chloro-1-methyl-pyridinium iodide; toluene-4-sulfonic acid; N,N-dimethylethylenediamine; triethylamine; In dichloromethane; toluene;
DOI:10.1021/om3007163