2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole

Base Information

Chemical Name:2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole
CAS No.:124779-26-6
Molecular Formula:C₃₅H₃₂ClN₃O₄
Molecular Weight:594.11
Hs Code.:

Synonyms:2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole

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Chemical Property of 2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole

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Technology Process of 2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole

There total 11 articles about 2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228-96-2
1-[(diphenylamino)carbonyl]pyridinium chloride

: 114798-27-5
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'carboxybiphenyl-4-yl)methyl]imidazole

: 124779-26-6
2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole

Guidance literature:: With sodium hydroxide; In methanol; at 25 ℃; for 0.75h;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 124779-26-6
2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 81 percent / 10percent aq. NaOH / ethanol / 14 h / Heating

7: 1.00 N aq. NaOH / methanol / 0.75 h / 25 °C

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; sodium methylate; acetyl chloride; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol;
DOI:10.1021/jm00112a031

Reference yield:

: 624-31-7
4-tolyl iodide

: 124779-26-6
2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 81 percent / 10percent aq. NaOH / ethanol / 14 h / Heating

5: 1.00 N aq. NaOH / methanol / 0.75 h / 25 °C

With sodium hydroxide; N-Bromosuccinimide; sodium methylate; copper; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol;
DOI:10.1021/jm00112a031