(S)-(+)-1-iodo-2-methylpentane

Base Information

• Chemical Name: (S)-(+)-1-iodo-2-methylpentane
• CAS No.: 161794-91-8
• Molecular Formula: C₆H₁₃I
• Molecular Weight: 212.074
• Mol file: 161794-91-8.mol

Synonyms:(S)-(+)-1-iodo-2-methylpentane

Chemical Property of (S)-(+)-1-iodo-2-methylpentane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(+)-1-iodo-2-methylpentane

There total 2 articles about (S)-(+)-1-iodo-2-methylpentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-amino-2-(methoxymethyl)pyrrolidine (59983-39-0,187035-29-6) → (S)-(+)-1-iodo-2-methylpentane (161794-91-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 98 percent / CH₂Cl₂ / 20 h / 20 °C

2.1: 2,2,6,6-tetramethylpiperidine; n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: tetrahydrofuran; hexane / 20 h / -78 - 20 °C

3.1: ag. HCl / pentane / 0.25 h / 20 °C

4.1: BH₃*Me₂S / diethyl ether; pentane / 0.75 h / 0 °C

5.1: pyridine / DMAP / CH₂Cl₂ / 30 h / 0 °C

6.1: lithiun iodide / tetrahydrofuran / 5 h / 20 °C

With pyridine; 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; dimethylsulfide borane complex; lithium iodide; dmap; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; pentane;

DOI:10.1039/b006832m

Reference yield:

(R)-1-Amino-2-(methoxymethyl)pyrrolidine (72748-99-3,187035-29-6) → (S)-(+)-1-iodo-2-methylpentane (161794-91-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 95 percent / CH₂Cl₂ / 20 h / 20 °C

2.1: 2,2,6,6-tetramethylpiperidine; n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: tetrahydrofuran; hexane / 20 h / -78 - 20 °C

3.1: ag. HCl / pentane / 0.25 h / 20 °C

4.1: BH₃*Me₂S / diethyl ether; pentane / 0.75 h / 0 °C

5.1: pyridine / DMAP / CH₂Cl₂ / 30 h / 0 °C

6.1: lithiun iodide / tetrahydrofuran / 5 h / 20 °C

With pyridine; 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; dimethylsulfide borane complex; lithium iodide; dmap; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; pentane;

DOI:10.1039/b006832m

Reference yield:

(S)-(+)-1-iodo-2-methylpentane (161794-91-8) → (3R,7S)-3,7-dimethyldecyl tosylate (161795-02-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) hexane, THF, HMPA, -30 deg C, 1 h; 2.) hexane, THF, HMPA, r.t., 12 h

2: 87 percent / Na-Hg / ethanol / 40 h / Ambient temperature

3: 96 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature

4: pyridine / 12 h / 0 - 5 °C

With pyridine; n-butyllithium; sodium amalgam; hydrogen; palladium on activated charcoal; In ethanol;

upstream raw materials:

(R)-1-Amino-2-(methoxymethyl)pyrrolidine

(S)-1-amino-2-(methoxymethyl)pyrrolidine

Downstream raw materials:

(3R,7S)-1-(benzyloxy)-3,7-dimethyldecane

(3S,7S)-1-(benzyloxy)-3,7-dimethyldecane

(3R,7S)-3,7-dimethyldecyl tosylate

(3S,7S)-3,7-dimethyldecyl tosylate