2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1612288-03-5
Molecular Formula:C₂₀H₁₅ClFN₃O
Molecular Weight:367.81
Hs Code.:

Synonyms:2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

There total 8 articles about 2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1612287-21-4
5-(6-methoxy-4-methylpyridin-3-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 127654-70-0
1-chloro-3-fluoro-2-iodobenzene

: 1612288-03-5
2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 183208-34-6
5-bromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

: 1612288-03-5
2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 5 h / 100 °C

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 6 h / 100 °C / Schlenk technique; Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; potassium acetate / 1,2-dimethoxyethane / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

4: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 1 h / 80 °C / Microwave irradiation; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; caesium carbonate; trichlorophosphate; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 1612287-22-5
2-chloro-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

: 1612288-03-5
2-(2-chloro-6-fluorophenyl)-5-(6-methoxy-4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; potassium acetate / 1,2-dimethoxyethane / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 1 h / 80 °C / Microwave irradiation; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water;