{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid

Base Information

Chemical Name:{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid
CAS No.:1312018-56-6
Molecular Formula:C₂₃H₂₆N₂O₄S
Molecular Weight:426.536
Hs Code.:

Synonyms:{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid

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Chemical Property of {2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid

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Technology Process of {2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid

There total 23 articles about {2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312016-70-8
{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetonitrile

: 64-19-7,77671-22-8
acetic acid

: 1312018-56-6
{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid

Guidance literature:: With hydrogenchloride; In water; for 2h; Reflux;

Reference yield:

: 271-63-6
7-Azaindole

: 1312018-56-6
{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid

Guidance literature:: Multi-step reaction with 20 steps

1.1: triethylamine; formic acid / palladium 10% on activated carbon / 120 h / 0 - 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 3 h / 0 °C

3.1: bromine; pyridine / dichloromethane / 2 h / 0 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h

5.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

5.2: 12.25 h / 0 - 25 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 85 °C

7.1: 1,4-bis(9-O-dihydroquinidine)phthalazine; water; methanesulfonamide / tert-butyl alcohol / 12 h / 0 °C

7.2: 0.5 h / 25 °C

8.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 25 °C

9.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 °C

9.2: 1 h / -78 °C

10.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

11.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

11.2: 1.5 h / -78 °C

12.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1.5 h / 100 °C / Microwave irradiation

13.1: sodium hydroxide; water / ethanol / 1 h / 100 °C

13.2: pH 4 - 5

14.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 50 °C / 37503.8 Torr

15.1: hydrogenchloride; water / tetrahydrofuran / 1 h / Reflux

16.1: sodium periodate / water; tetrahydrofuran / 2 h / 0 - 20 °C

17.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

18.1: thionyl chloride / dichloromethane / 2 h / 0 °C

19.1: N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

20.1: hydrogenchloride / water / 2 h / Reflux

With pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; sodium periodate; formic acid; thionyl chloride; methanesulfonamide; tetrabutylammomium bromide; water; hydrogen; bromine; sodium hydride; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 766-00-7
2-cyclopentyl-ethanol

: 1312018-56-6
{2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-acetic acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: pyridinium chlorochromate / dichloromethane / 3 h / 25 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 °C

2.2: 1 h / -78 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

4.2: 1.5 h / -78 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1.5 h / 100 °C / Microwave irradiation

6.1: sodium hydroxide; water / ethanol / 1 h / 100 °C

6.2: pH 4 - 5

7.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 50 °C / 37503.8 Torr

8.1: hydrogenchloride; water / tetrahydrofuran / 1 h / Reflux

9.1: sodium periodate / water; tetrahydrofuran / 2 h / 0 - 20 °C

10.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

11.1: thionyl chloride / dichloromethane / 2 h / 0 °C

12.1: N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

13.1: hydrogenchloride / water / 2 h / Reflux

With hydrogenchloride; methanol; sodium tetrahydroborate; sodium periodate; thionyl chloride; water; hydrogen; sodium carbonate; Dess-Martin periodane; pyridinium chlorochromate; sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;