ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate

Base Information

• Chemical Name: ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate
• CAS No.: 247073-81-0
• Molecular Formula: C₂₃H₃₁NO₅
• Molecular Weight: 401.503
• Mol file: 247073-81-0.mol

Synonyms:ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate

Chemical Property of ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate

There total 5 articles about ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-((1R,2S)-2-amino-1-hydroxypropyl)phenol (552-85-2,771-91-5,1926-72-3,13104-32-0,37692-93-6,52446-53-4,62928-85-2,62928-86-3,73027-12-0) + ethyl 2-[4-(2-bromoethyl)phenoxy]-2-methylpropionate (167213-40-3) → ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate (247073-81-0)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 4h;

DOI:10.1016/S0968-0896(01)00240-1

Reference yield:

ethyl 2-methyl-2-phenoxypropanoate (18672-04-3) → ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate (247073-81-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 23 percent / AlCl₃ / CH₂Cl₂ / 6 h / Heating

2: 96 percent / triethylsilane; TFA / 1 h / 70 °C

3: 67 percent / dimethylformamide / 4 h / 70 °C

With triethylsilane; aluminium trichloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;

DOI:10.1016/S0968-0896(01)00240-1

Reference yield:

ethyl 2-[4-(bromoacetyl)phenoxy]-2-methylpropionate (62734-46-7) → ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate (247073-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / triethylsilane; TFA / 1 h / 70 °C

2: 67 percent / dimethylformamide / 4 h / 70 °C

With triethylsilane; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00240-1

upstream raw materials:

4-((1R,2S)-2-amino-1-hydroxypropyl)phenol

ethyl 2-[4-(2-bromoethyl)phenoxy]-2-methylpropionate

ethyl 2-methyl-2-phenoxypropanoate

ethyl 2-[4-(bromoacetyl)phenoxy]-2-methylpropionate