Propanoic acid, 2-[4-(bromoacetyl)phenoxy]-2-methyl-, ethyl ester

Base Information

• Chemical Name: Propanoic acid, 2-[4-(bromoacetyl)phenoxy]-2-methyl-, ethyl ester
• CAS No.: 62734-46-7
• Molecular Formula: C14H17BrO4
• Molecular Weight: 329.191
• Mol file: 62734-46-7.mol

Synonyms:ethyl 2-(4-bromoacetylphenoxy)isobutyrate;ethyl 2-[4-(2-bromoacetyl)phenoxy]-2-methylpropanoate;

Chemical Property of Propanoic acid, 2-[4-(bromoacetyl)phenoxy]-2-methyl-, ethyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 2.98470

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 2-[4-(bromoacetyl)phenoxy]-2-methyl-, ethyl ester

There total 4 articles about Propanoic acid, 2-[4-(bromoacetyl)phenoxy]-2-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.6%

ethyl 2-methyl-2-(4-acetylphenyl)oxypropionate (29884-24-0) → ethyl 2-[4-(bromoacetyl)phenoxy]-2-methylpropionate (62734-46-7)

Guidance literature:

With copper(ll) bromide; In chloroform; ethyl acetate; for 0.416667h; Heating;

Reference yield: 23.0%

ethyl 2-methyl-2-phenoxypropanoate (18672-04-3) + 2-Bromoacetyl bromide (598-21-0) → ethyl 2-[4-(bromoacetyl)phenoxy]-2-methylpropionate (62734-46-7)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 6h; Heating;

DOI:10.1016/S0968-0896(01)00240-1

Reference yield:

phenol (108-95-2,27073-41-2) → ethyl 2-[4-(bromoacetyl)phenoxy]-2-methylpropionate (62734-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOH / acetone / 20 °C

1.2: 77 percent / SOCl₂ / 6 h / Heating

2.1: 23 percent / AlCl₃ / CH₂Cl₂ / 6 h / Heating

With sodium hydroxide; aluminium trichloride; In dichloromethane; acetone; 2.1: Friedel-Crafts reaction;

DOI:10.1016/S0968-0896(01)00240-1

upstream raw materials:

ethyl 2-methyl-2-phenoxypropanoate

2-Bromoacetyl bromide

phenol

ethyl 2-methyl-2-(4-acetylphenyl)oxypropionate

Downstream raw materials:

ethyl 2-[4-(2-bromoethyl)phenoxy]-2-methylpropionate

ethyl 2-{4-[2-(5-(2,3-dicarbobenzoxy-1-guanidino)-1-oxo-2,3-dihydro-1H-benzo[c]azol-2-yl)acetyl]phenoxy}-2-methylpropanoate

ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate