4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile

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Chemical Name:4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile
CAS No.:1178953-04-2
Molecular Formula:C₃₁H₂₉F₃N₆O₃
Molecular Weight:590.605
Hs Code.:

Synonyms:4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile

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Chemical Property of 4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile

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Technology Process of 4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile

There total 9 articles about 4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178953-41-7
benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

: 1178953-04-2
4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; under 1500.15 Torr;

Reference yield:

: 143782-20-1
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 1178953-04-2
4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 5 h / 20 °C

2.1: caesium carbonate; Benzophenone imine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 95 °C / Inert atmosphere

2.2: 0.17 h / 20 °C

3.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 60 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1500.15 Torr

With Benzophenone imine; hydrogen; potassium carbonate; caesium carbonate; palladium 10% on activated carbon; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; acetonitrile;

Reference yield:

: 143782-18-7
4-isocyanato-2-(trifluoromethyl)benzonitrile

: 1178953-04-2
4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / acetonitrile / 0.75 h / 20 °C

2.1: hydrogenchloride / acetonitrile; water / 1 h / 70 °C

3.1: potassium carbonate / acetonitrile / 5 h / 20 °C

4.1: caesium carbonate; Benzophenone imine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 95 °C / Inert atmosphere

4.2: 0.17 h / 20 °C

5.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 60 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / methanol / 1500.15 Torr

With hydrogenchloride; Benzophenone imine; hydrogen; potassium carbonate; caesium carbonate; triethylamine; palladium 10% on activated carbon; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; water; acetonitrile;