benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

Base Information

Chemical Name:benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate
CAS No.:1178953-41-7
Molecular Formula:C₃₉H₃₅F₃N₆O₅
Molecular Weight:724.739
Hs Code.:

benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

Synonyms:benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

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Chemical Property of benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

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Technology Process of benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

There total 11 articles about benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 239072-89-0
benzyl 4-(4-bromobenzyl)-3-oxopiperazine-1-carboxylate

: 1006898-92-5
4-[3-(2-aminobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

: 1178953-41-7
benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 60 ℃; for 6h; Inert atmosphere;

Reference yield:

: 143782-20-1
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 1178953-41-7
benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 5 h / 20 °C

2.1: caesium carbonate; Benzophenone imine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 95 °C / Inert atmosphere

2.2: 0.17 h / 20 °C

3.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 60 °C / Inert atmosphere

With Benzophenone imine; potassium carbonate; caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; acetonitrile;

Reference yield:

: 143782-18-7
4-isocyanato-2-(trifluoromethyl)benzonitrile

: 1178953-41-7
benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / acetonitrile / 0.75 h / 20 °C

2.1: hydrogenchloride / acetonitrile; water / 1 h / 70 °C

3.1: potassium carbonate / acetonitrile / 5 h / 20 °C

4.1: caesium carbonate; Benzophenone imine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 95 °C / Inert atmosphere

4.2: 0.17 h / 20 °C

5.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 60 °C / Inert atmosphere

With hydrogenchloride; Benzophenone imine; potassium carbonate; caesium carbonate; triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; acetonitrile;