2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

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Chemical Name:2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one
CAS No.:1408085-09-5
Molecular Formula:C₃₀H₂₂F₃N₅O₃
Molecular Weight:557.532
Hs Code.:

Synonyms:2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

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Chemical Property of 2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

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Technology Process of 2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

There total 13 articles about 2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1408087-70-6
2-(bromomethyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

: 1408087-64-8
3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1408085-09-5
2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 120484-50-6
1-(2-Fluoro-6-methoxyphenyl)ethanone

: 1408085-09-5
2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C

2.1: pyridine / dichloromethane / 3 h / 45 °C / Cooling with ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 6 h / -78 - 20 °C

3.2: 4 h / Reflux

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 20 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / Inert atmosphere; Reflux

6.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / 80 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; aluminum (III) chloride; N-Bromosuccinimide; potassium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 93339-98-1
1-(2-fluoro-6-hydroxyphenyl)ethan-1-one

: 1408085-09-5
2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 3 h / 45 °C / Cooling with ice

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 6 h / -78 - 20 °C

2.2: 4 h / Reflux

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / Inert atmosphere; Reflux

5.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / 80 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; N-Bromosuccinimide; potassium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;