N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide

Base Information

Chemical Name:N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide
CAS No.:1255701-38-2
Molecular Formula:C₂₂H₃₀Cl₂N₂O₃Si
Molecular Weight:469.483
Hs Code.:

Synonyms:N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide

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Technology Process of N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide

There total 1 articles about N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1255701-39-3
2-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-phenylethanol

: 58584-83-1
2,6-dichloronicotinoyl chloride

: 1255701-38-2
N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 98.0%

: 1255701-38-2
N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide

: 1255701-37-1
4-(2-(tert-butyldimethylsilyloxy)ethyl)-8-chloro-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

Guidance literature:: With sodium t-butanolate; In 1,4-dioxane; at 10 - 15 ℃;

Reference yield:

: 1255701-38-2
N-(2-(tert-butyldimethylsilyloxy)ethyl)-2,6-dichloro-N-(2-hydroxy-2-phenylethyl)nicotinamide

: 1255700-50-5
4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / 1,4-dioxane / 10 - 15 °C

2: caesium carbonate / palladium diacetate / 1,2-dimethoxyethane / 1 h / 100 °C / Sealed microwave vial; Inert atmosphere

3: tetrabutyl ammonium fluoride / 1,2-dimethoxyethane / 1.5 h / 20 °C

With tetrabutyl ammonium fluoride; caesium carbonate; sodium t-butanolate; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane;