4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

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Chemical Name:4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one
CAS No.:1255700-50-5
Molecular Formula:C₂₆H₂₅N₅O₃
Molecular Weight:455.516
Hs Code.:

Synonyms:4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

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Chemical Property of 4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

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Technology Process of 4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

There total 6 articles about 4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₉N₅O₃Si

: 1255700-50-5
4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In 1,2-dimethoxyethane; at 20 ℃; for 1.5h;

Reference yield:

: 1255701-39-3
2-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-phenylethanol

: 1255700-50-5
4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: sodium t-butanolate / 1,4-dioxane / 10 - 15 °C

3: caesium carbonate / palladium diacetate / 1,2-dimethoxyethane / 1 h / 100 °C / Sealed microwave vial; Inert atmosphere

4: tetrabutyl ammonium fluoride / 1,2-dimethoxyethane / 1.5 h / 20 °C

With tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; sodium t-butanolate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane;

Reference yield:

: 1255701-37-1
4-(2-(tert-butyldimethylsilyloxy)ethyl)-8-chloro-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

: 1255700-50-5
4-(2-hydroxyethyl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / palladium diacetate / 1,2-dimethoxyethane / 1 h / 100 °C / Sealed microwave vial; Inert atmosphere

2: tetrabutyl ammonium fluoride / 1,2-dimethoxyethane / 1.5 h / 20 °C

With tetrabutyl ammonium fluoride; caesium carbonate; palladium diacetate; In 1,2-dimethoxyethane;