N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Base Information

• Chemical Name: N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine
• CAS No.: 1438074-57-7
• Molecular Formula: C₂₆H₂₉N₅O₂
• Molecular Weight: 443.549
• Mol file: 1438074-57-7.mol

Synonyms:N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Chemical Property of N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine

There total 12 articles about N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

tert-butyl 5-(3-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (1438085-67-6) → N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine (1438074-57-7)

Guidance literature:

With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 6h;

Reference yield:

6-acetoxy-4-chloro-7-methoxyquinazoline (230955-75-6) → N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine (1438074-57-7)

Guidance literature:

Multi-step reaction with 5 steps

1: isopropyl alcohol / 83 °C

2: methanol; sodium hydroxide / 5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 - 40 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

5: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C

With hydrogenchloride; methanol; potassium carbonate; potassium iodide; sodium hydroxide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione (848591-86-6) → N-(3-ethynylphenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine (1438074-57-7)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 °C / Reflux

2: dichloromethane / 0 - 20 °C

3: hydrogen; palladium(II) hydroxide / methanol

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

5: hydrogenchloride / dichloromethane; ethyl acetate / 6 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; palladium(II) hydroxide; potassium carbonate; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione

2-benzyloctahydropyrrolo[3,4-c]pyrrole

tert-butyl 5-benzylhexahydropyrrolo[3.4-c]pyrrole-2(1H)-carboxylate

tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate