3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide

Base Information

• Chemical Name: 3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide
• CAS No.: 1335295-37-8
• Molecular Formula: C₂₅H₂₉BrOSi
• Molecular Weight: 453.494
• Mol file: 1335295-37-8.mol

Synonyms:3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide

Chemical Property of 3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide

There total 2 articles about 3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(3-bromopropyl)phenol (52273-55-9) + tert-butylchlorodiphenylsilane (58479-61-1) → 3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide (1335295-37-8)

Guidance literature:

4-(3-bromopropyl)phenol; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃;

tert-butylchlorodiphenylsilane; In tetrahydrofuran; at 0 ℃;

DOI:10.1002/jccs.201190026

Reference yield:

3-(4-hydroxyphenyl)propan-1-ol (10210-17-0) → 3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide (1335295-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / Cooling with ice

2.1: potassium tert-butylate / tetrahydrofuran / 0 °C

2.2: 0 °C

With carbon tetrabromide; potassium tert-butylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1.1: Appel reaction;

DOI:10.1002/jccs.201190026

Reference yield: 93.0%

3-(4-((tert-butyl)diphenylsiloxy)phenyl)propyl bromide (1335295-37-8) + allylmagnesium bromide (2622-05-1) → 6-(4-((tert-butyl)diphenylsiloxy)phenyl)hex-1-ene (1335295-39-0)

Guidance literature:

In tetrahydrofuran; toluene; at 0 - 95 ℃; for 36h;

DOI:10.1002/jccs.201190026

upstream raw materials:

3-(4-hydroxyphenyl)propan-1-ol

4-(3-bromopropyl)phenol

tert-butylchlorodiphenylsilane

Downstream raw materials:

6-(4-((tert-butyl)diphenylsiloxy)phenyl)hex-1-ene

Refernces