N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide

Base Information

• Chemical Name: N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide
• CAS No.: 1395059-92-3
• Molecular Formula: C₁₈H₁₈INO₂
• Molecular Weight: 407.251
• Mol file: 1395059-92-3.mol

Synonyms:N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide

Chemical Property of N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide

There total 5 articles about N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-ethyl-2-vinylaniline (1395060-14-6) + 2-iodo-5-methoxybenzoic acid (54413-93-3) → N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide (1395059-92-3)

Guidance literature:

2-iodo-5-methoxybenzoic acid; With Vilsmeier reagent; In dichloromethane; at 0 - 20 ℃; for 0.5h;

4-ethyl-2-vinylaniline; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1021/jm3002394

Reference yield:

5-hydroxy-2-iodo-benzoic acid (57772-57-3) → N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide (1395059-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 5 h / Reflux

2.1: sodium hydroxide / water; methanol / 2 h / Reflux

3.1: Vilsmeier reagent / dichloromethane / 0.5 h / 0 - 20 °C

3.2: 12 h / 0 - 20 °C

With Vilsmeier reagent; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; water; acetone;

DOI:10.1021/jm3002394

Reference yield:

2-bromine-4-ethylaniline (38678-86-3) → N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide (1395059-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / 100 °C / Inert atmosphere

2.1: Vilsmeier reagent / dichloromethane / 0.5 h / 0 - 20 °C

2.2: 12 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Vilsmeier reagent; In dichloromethane; toluene;

DOI:10.1021/jm3002394

upstream raw materials:

2-bromine-4-ethylaniline

4-ethyl-2-vinylaniline

2-iodo-5-methoxybenzoic acid

2-amino-5-hydroxybenzoic acid

Downstream raw materials:

N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxy-N-methylbenzamide

ethyl 3-(5,11-dihydro-2-ethyl-5-methyl-11-methylene-6-oxodibenz[b,e]azepin-8-yl)benzoate

methyl 4-(5,11-dihydro-2-ethyl-5-methyl-11-methylene-6-oxodibenz[b,e]azepin-8-yl)benzoate

methyl 2-(3-(5,11-dihydro-2-ethyl-5-methyl-11-methylene-6-oxodibenz[b,e]azepin-8-yl)phenyl)acetate