3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid

Base Information

Chemical Name:3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid
CAS No.:1428527-72-3
Molecular Formula:C₁₆H₁₄N₅O₅P
Molecular Weight:387.291
Hs Code.:

Synonyms:3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid

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Chemical Property of 3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid

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Technology Process of 3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid

There total 6 articles about 3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1428527-71-2
diethyl 3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenyl-phosphonate

: 1428527-72-3
3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 30 ℃;

Reference yield:

: ethyl 2-(3-(diethoxyphosphoryl)phenyl)acetate

: 1428527-72-3
3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / ethanol; water

2: triethylamine; HATU / acetonitrile / 20 °C

3: trimethylsilyl bromide / dichloromethane / 30 °C

With lithium hydroxide monohydrate; trimethylsilyl bromide; triethylamine; HATU; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1428527-72-3
3-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidin-5-ylamino)-2-oxoethyl)phenylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / 110 °C

3: lithium hydroxide monohydrate / ethanol; water

4: triethylamine; HATU / acetonitrile / 20 °C

5: trimethylsilyl bromide / dichloromethane / 30 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; trimethylsilyl bromide; sulfuric acid; triethylamine; HATU; In ethanol; dichloromethane; water; toluene; acetonitrile;