(+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide

Base Information

Chemical Name:(+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide
CAS No.:150254-86-7
Molecular Formula:C₁₉H₂₄N₂O₄
Molecular Weight:344.411
Hs Code.:

Synonyms:(+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide

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Chemical Property of (+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide

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Technology Process of (+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide

There total 5 articles about (+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: (+/-)-N-(4-Aminobutyl)-3-methylsuccinimide hydrochloride

: 150254-86-7
(+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 1h; Heating;
DOI:10.1016/S0040-4020(01)81286-2

Reference yield:

: 5615-90-7,117307-07-0,128562-06-1,132295-22-8
3-methylsuccinimide

: 150254-86-7
(+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Na, MeOH / 2.) DMF, reflux, 1 h

2: 5.70 g / H₂, conc. aq. HCl / PtO₂ / ethanol / 8 h

3: 92 percent / 1-methyl-2-chloropyridinium iodide, Et₃N / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; methanol; 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)81286-2

Reference yield:

: 1072-87-3
citraconimide

: 150254-86-7
(+/-)-(E)-3-(4-Methoxyphenyl)-N-<4-(3-methyl-2,5-dioxo-1-pyrrolidinyl)butyl>-2-propenamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / 10percent Pd-C / ethanol / 760 Torr

2: 1.) Na, MeOH / 2.) DMF, reflux, 1 h

3: 5.70 g / H₂, conc. aq. HCl / PtO₂ / ethanol / 8 h

4: 92 percent / 1-methyl-2-chloropyridinium iodide, Et₃N / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; methanol; 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)81286-2