(R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine

Base Information

Chemical Name:(R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine
CAS No.:201732-39-0
Molecular Formula:C₃₂H₃₈N₂O₅Si
Molecular Weight:558.75
Hs Code.:

Synonyms:(R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine

Suppliers and Price of (R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine

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Technology Process of (R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine

There total 6 articles about (R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 201732-38-9
((R)-3-Benzyloxy-2-chloromethoxy-propoxy)-tert-butyl-diphenyl-silane

: 7288-28-0
2,4-bis(trimethylsiloxy)-5-methylpyrimidine

: 201732-39-0
(R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine

Guidance literature:: With tin(IV) chloride; In acetonitrile; for 1.16667h; ice-water cooling;
DOI:10.1016/S0040-4020(97)10289-7

Reference yield:

: 17325-85-8
(2S)-3-(benzyloxy)propane-1,2-diol

: 201732-39-0
(R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 20 °C

2: HCl / CH₂Cl₂ / -4 - 0 °C

3: 80 percent / SnCl₄ / acetonitrile / 1.17 h / ice-water cooling

With hydrogenchloride; dmap; tin(IV) chloride; triethylamine; In dichloromethane; acetonitrile; 1: silylation / 2: Alkylation / 3: Substitution;
DOI:10.1016/S0040-4020(97)10289-7

Reference yield:

: 100-39-0
benzyl bromide

: 201732-39-0
(R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 0.17 h

1.2: 96 percent / tetrahydrofuran / 3 h / 20 °C

2.1: 99 percent / conc. HCl / methanol; CH₂Cl₂ / 0.17 h

3.1: 90 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 20 °C

4.1: HCl / CH₂Cl₂ / -4 - 0 °C

5.1: 80 percent / SnCl₄ / acetonitrile / 1.17 h / ice-water cooling

With hydrogenchloride; dmap; tin(IV) chloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 1.1: Metallation / 1.2: Etherification / 2.1: Hydrolysis / 3.1: silylation / 4.1: Alkylation / 5.1: Substitution;
DOI:10.1016/S0040-4020(97)10289-7