N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

Base Information

Chemical Name:N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine
CAS No.:1072906-83-2
Molecular Formula:C₃₃H₃₇F₉N₄O₂S
Molecular Weight:724.734
Hs Code.:

N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

Synonyms:N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

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Chemical Property of N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

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Technology Process of N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

There total 11 articles about N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1072906-82-1
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

: 1072906-83-2
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

: 1072906-84-3
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-amine

Guidance literature:: With dihydrogen peroxide; dioxomolybdenum(VI) dichloride; In water; acetonitrile; at 20 ℃; for 23h;

Reference yield:

: 1006599-54-7
2-amino-5-[2-(methylthio)ethoxy]pyrimidine

: 1072906-83-2
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

: 1072906-84-3
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / toluene / 4 h / Heating / reflux

2.1: sodium tris(acetoxy)borohydride / acetic acid; toluene / 60 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 50 °C

3.2: 2.5 h / -78 - 20 °C

4.1: dihydrogen peroxide / dioxomolybdenum(VI) dichloride / water; acetonitrile / 23 h / 20 °C

With dihydrogen peroxide; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; dioxomolybdenum(VI) dichloride; In tetrahydrofuran; water; acetic acid; toluene; acetonitrile;

Reference yield:

: 1006599-53-6
N-(4-methoxybenzyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine

: 1072906-83-2
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfinyl)ethoxy]pyrimidin-2-amine

: 1072906-84-3
N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 2.5 h / 60 °C

2.1: acetic acid / toluene / 4 h / Heating / reflux

3.1: sodium tris(acetoxy)borohydride / acetic acid; toluene / 60 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 50 °C

4.2: 2.5 h / -78 - 20 °C

5.1: dihydrogen peroxide / dioxomolybdenum(VI) dichloride / water; acetonitrile / 23 h / 20 °C

With dihydrogen peroxide; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; trifluoroacetic acid; dioxomolybdenum(VI) dichloride; In tetrahydrofuran; water; acetic acid; toluene; acetonitrile;