3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole

Base Information

• Chemical Name: 3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole
• CAS No.: 1415127-44-4
• Molecular Formula: C₁₈H₁₈BrN₃
• Molecular Weight: 356.265
• Mol file: 1415127-44-4.mol

Synonyms:3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole

Chemical Property of 3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole

There total 2 articles about 3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C13H16BrNO2 (1415127-42-2) + o-tolylhydrazine hydrochloride (635-26-7) → 3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole (1415127-44-4)

Guidance literature:

o-tolylhydrazine hydrochloride; With triethylamine; In tetrachloromethane; at 20 ℃; for 1h;

C₁₃H₁₆BrNO₂; In tetrachloromethane; at 20 ℃; for 48h;

Reference yield:

3-bromobenzenecarboximidic acid ethyl ester monohydrochloride (57508-63-1) → 3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole (1415127-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / toluene / 0.17 h / 20 °C

1.2: 24 h / 20 °C

2.1: triethylamine / tetrachloromethane / 1 h / 20 °C

2.2: 48 h / 20 °C

With triethylamine; In tetrachloromethane; toluene;

Reference yield: 84.0%

3-(3-bromophenyl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole (1415127-44-4) + phenylboronic acid (98-80-6) → 3-(biphenyl-3-yl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole (1415127-46-6)

Guidance literature:

With potassium carbonate; palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; water; toluene; at 80 ℃; for 10h; Inert atmosphere;

upstream raw materials:

3-bromobenzenecarboximidic acid ethyl ester monohydrochloride

C₁₃H₁₆BrNO₂

o-tolylhydrazine hydrochloride

Downstream raw materials:

3-(biphenyl-3-yl)-1-(2-methylphenyl)-5-propyl-1H-1,2,4-triazole