N⁴-isopropyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine

Base Information

• Chemical Name: N⁴-isopropyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine
• CAS No.: 1350545-39-9
• Molecular Formula: C₁₈H₂₅N₇O₂
• Molecular Weight: 371.442

Synonyms:N⁴-isopropyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine

Chemical Property of N⁴-isopropyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N⁴-isopropyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine

There total 4 articles about N⁴-isopropyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.1%

2-chloro-N-isopropyl-5-nitropyrimidin-4-amine (890094-38-9) + 4-(4-Methyl-piperazino)-anilin (16153-81-4) → N4-isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine (1350545-39-9)

Guidance literature:

In butan-1-ol; at 90 ℃; for 3h;

Reference yield:

1-methyl-piperazine (109-01-3) → N4-isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine (1350545-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 6 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 9 h / 20 °C

3.1: butan-1-ol / 5 h / 90 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; dimethyl sulfoxide; butan-1-ol;

DOI:10.1021/jm301365e

Reference yield:

1-methyl-4-(4-nitrophenyl)piperazine (16155-03-6) → N4-isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine (1350545-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 9 h / 20 °C

2: butan-1-ol / 5 h / 90 °C

With palladium 10% on activated carbon; hydrogen; In ethanol; butan-1-ol;

DOI:10.1021/jm301365e

upstream raw materials:

1-methyl-piperazine

4-Fluoronitrobenzene

1-methyl-4-(4-nitrophenyl)piperazine

2-chloro-N-isopropyl-5-nitropyrimidin-4-amine

Downstream raw materials:

4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

9-isopropyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-8-phenylamino-9H-purine

8-(3-bromophenylamino)-9-isopropyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

8-(3-ethynylphenylamino)-9-isopropyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

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