2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

Base Information

Chemical Name:2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine
CAS No.:1377578-81-8
Molecular Formula:C₁₃H₉FN₂
Molecular Weight:212.226
Hs Code.:

Synonyms:2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

Suppliers and Price of 2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

There total 8 articles about 2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 130995-12-9
1-(4-fluorophenyl)-2-trimethylsilylacetylene

: N-(3-iodopyridin-4-yl)acetamide

: 1377578-81-8
2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl-ammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 48h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo300481s

Reference yield:

: 504-24-5
4-aminopyridine

: 1377578-81-8
2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; sodium carbonate; potassium iodide / water / 16 h / Inert atmosphere; Reflux

2.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl-ammonium chloride; potassium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl-ammonium chloride; iodine; sodium carbonate; potassium carbonate; triethylamine; potassium iodide; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo300481s

Reference yield:

: C₁₇H₂₄N₂O₆

: 1377578-81-8
2-(4-fluorophenyl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 - 23 °C / Inert atmosphere

1.2: -10 - 20 °C / Inert atmosphere

2.1: pyridine; thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: 3-(2,6-diethylphenyl)-4,5-dimethylthiazol-3-ium perchlorate; caesium carbonate / 1,4-dioxane / 36 h / 23 °C / Inert atmosphere; Glovebox

4.1: methanesulfonic acid / 40 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; thionyl chloride; methanesulfonic acid; 3-(2,6-diethylphenyl)-4,5-dimethylthiazol-3-ium perchlorate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1039/c6cc04735a