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130995-12-9

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130995-12-9 Usage

General Description

(4-Fluorophenylethynyl)trimethylsilane is a chemical compound that consists of a fluoro-substituted phenylacetylene group attached to a trimethylsilyl group. It is commonly used as a building block in organic synthesis, particularly in the construction of pharmaceuticals and agrochemicals. (4-FLUOROPHENYLETHYNYL)TRIMETHYLSILANE is known for its ability to introduce a fluorine atom into organic molecules, which can affect their physical and chemical properties. Additionally, it is an important reagent in the field of organometallic chemistry, where it can participate in various synthetic transformations and functional group interconversions. Overall, (4-Fluorophenylethynyl)trimethylsilane is a versatile and valuable chemical reagent with a wide range of applications in chemical research and production.

Check Digit Verification of cas no

The CAS Registry Mumber 130995-12-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,9,9 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 130995-12:
(8*1)+(7*3)+(6*0)+(5*9)+(4*9)+(3*5)+(2*1)+(1*2)=129
129 % 10 = 9
So 130995-12-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H13FSi/c1-13(2,3)9-8-10-4-6-11(12)7-5-10/h4-7H,1-3H3

130995-12-9 Well-known Company Product Price

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  • Aldrich

  • (563463)  (4-Fluorophenylethynyl)trimethylsilane  97%

  • 130995-12-9

  • 563463-5ML

  • 758.16CNY

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130995-12-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-fluorophenyl)ethynyl-trimethylsilane

1.2 Other means of identification

Product number -
Other names 1-(4-fluorophenyl)-2-trimethylsilylacetylene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:130995-12-9 SDS

130995-12-9Relevant articles and documents

Design of multilayered polymeric dielectric insulators for advanced microelectronics packaging

Park,Chiesel,Economy

, p. 351 - 363 (1994)

2,2-Bis[ 4-{ (4-fluorophenyl)buta-1,3-diynyl} phenyloxyphenyl] hexafluoropropane and co-polymer of 1,4-bis(4-fluorophenyl)buta-1,3-diyne and hexafluorobisphenol-A were prepared for the use as photosensitive multilayered polymeric dielectric insulators. Th

Alkyne oxidations by cis-dioxoruthenium(VI) complexes. A formal [3 + 2] cycloaddition reaction of alkynes with cis-[(Cn*)(CF3CO2)Ru(VI)O2]ClO4 (Cn* = 1,4,7-trimethyl-1,4,7-triazacyclononane)

Che,Yu,Chan,Cheng,Peng,Lau,Li

, p. 11380 - 11392 (2000)

cis-Dioxoruthenium(VI) complexes, [Cn*(CF3CO2)Ru(VI)O2]ClO4 (1) (Cn* = 1,4,7-trimethyl-1,4,7-triazacyclononane) and cis-[(Tet-Me6)Ru(VI)O2](ClO4)2 (2) (Tet-Me6 = N,N,N',N'-tetramethyl-3,6-dimethyl-3,6-diazaoctane-1,8-diamine), oxidize disubstituted alkynes to 1,2-diketones selectively in good to excellent yields under ambient conditions. The reactions proceed via the formation of dark blue [(Cn*)(CF3CO2)Ru(IV)OC2R1R2O]+ intermediates, which display a characteristic UV-visible absorption band at 550-680 nm. With bis(trimethylsilyl)acetylene as substrate and 1 as the oxidant, the intermediate was isolated and structurally characterized by X-ray crystallography as a [3 + 2] cycloadduct. The kinetics of the cycloaddition of 1 with various substituted trimethylsilylacetylenes has been studied by stopped-flow spectrophotometry. With the exception of bis(trimethylsilyl)acetylene, the second-order rate constants were found to vary over a range of less than an order of magnitude irrespective of a 2.3 eV change of the calculated I(p) of the alkynes; therefore, a rate-limiting single electron-transfer mechanism is unlikely. The participation of oxirene (oxene insertion) and metallaoxetene ([2 + 2] cycloaddition) intermediates appears to be implausible based on product analysis. A linear Hammett correlation was established using σ+ and σ(jj)(G) parameters for the cycloaddition of 1 with para-substituted aryl trimethylsilylacetylenes, and the rate-limiting vinyl radical intermediate formation is proposed.

Inverting Conventional Chemoselectivity in the Sonogashira Coupling Reaction of Polyhalogenated Aryl Triflates with TMS-Arylalkynes

Wang, Miao,So, Chau Ming

supporting information, p. 681 - 685 (2022/01/20)

A newly developed phosphine ligand with a C2-cyclohexyl group on the indole ring was successfully applied in a chemoselective Sonogashira coupling reaction with excellent chemoselectivity, affording an inversion of the conventional chemoselectivity order of C–Br > C–Cl > C–OTf. This study also provided an efficient approach to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and the natural product analogue trimethyl-selaginellin L by merging of chemoselective Sonogashira and Suzuki–Miyaura coupling reactions.

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Luo, Xiaosheng,Wang, Ping

supporting information, p. 4960 - 4965 (2021/07/20)

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

Synthesis of Phenanthrenes via Palladium-Catalyzed Three-Component Domino Reaction of Aryl Iodides, Internal Alkynes, and o-Bromobenzoic Acids

Deng, Guobo,Liang, Yun,Luo, Xiai,Yang, Xiumei,Yang, Yuan,Yang, Yuzhong,Zhou, Liwei

supporting information, p. 1223 - 1230 (2020/04/15)

A new palladium-catalyzed domino alkyne insertion/C-H activation/decarboxylation sequence has been developed, which provides an efficient approach for synthesizing a variety of functionalized phenanthrenes in moderate to good yields. The method shows broad substrate scope and good functional group tolerance by employing readily available materials, including aryl iodides, internal alkynes, and o-bromobenzoic acids, as three-component coupling partners.

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