1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

Base Information

Chemical Name:1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone
CAS No.:155432-24-9
Molecular Formula:C₁₉H₁₅F₅N₄O₃
Molecular Weight:442.345
Hs Code.:

Synonyms:1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

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Chemical Property of 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

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Technology Process of 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

There total 11 articles about 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155432-23-8
1-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

: Trifluoro-methanesulfonic acid (S)-1-[(R)-2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl ester

: 155432-24-9
1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

: (2R)-2-(2,4-difluorophenyl)-2-[(1R)-1-[1-[4-(2,2,2-trifluoroethoxy)phenyl]-1H-tetrazol-5-yloxy]ethyl]oxirane

Guidance literature:: With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; at -10 - 0 ℃; for 0.5h; Title compound not separated from byproducts;
DOI:10.1248/cpb.44.314

Reference yield:

: 155432-23-8
1-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

: (1S)-1-[2-(2,4-difluorophenyl)-2-oxiranyl]ethanol

: 155432-24-9
1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

: (2R)-2-(2,4-difluorophenyl)-2-[(1R)-1-[1-[4-(2,2,2-trifluoroethoxy)phenyl]-1H-tetrazol-5-yloxy]ethyl]oxirane

Guidance literature:

Reference yield:

: 27914-56-3
4-(2,2,2-trifluoroethoxy)benzoic acid

: 155432-24-9
1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, ethyl chloroformate, 2.) NaN₃, Bu₄NHSO₄

2: TMSN₃ / 18 h / 110 °C

3: NaH / CH₂Cl₂; dimethylformamide / 0.5 h / -10 - 0 °C

With sodium azide; trimethylsilylazide; tetra(n-butyl)ammonium hydrogensulfate; chloroformic acid ethyl ester; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.314