(R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

Base Information

Chemical Name:(R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide
CAS No.:1174540-21-6
Molecular Formula:C₃₀H₂₇ClF₄N₄O₄S
Molecular Weight:651.081
Hs Code.:

(R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

Synonyms:(R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

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Chemical Property of (R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

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Technology Process of (R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

There total 9 articles about (R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.9%

: 238754-67-1
2-(3-fluoro-4-(trifluoromethyl)phenyl)acetic acid

: 1174540-28-3
2-((R)-(1-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methylamino)ethyl)-3-(4-chlorophenyl)pyrido[2,3d]pyrimidin-4(3H)-one

: 1174540-21-6
(R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

: 1262797-01-2
C₃₀H₂₇ClF₄N₄O₄S

Guidance literature:: 2-(3-fluoro-4-(trifluoromethyl)phenyl)acetic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; for 0.333333h; Inert atmosphere; Large scale reaction;

2-((R)-(1-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methylamino)ethyl)-3-(4-chlorophenyl)pyrido[2,3d]pyrimidin-4(3H)-one; In acetonitrile; for 21h;
DOI:10.1021/jo102399a

Reference yield:

: 238754-67-1
2-(3-fluoro-4-(trifluoromethyl)phenyl)acetic acid

: 1174540-28-3
2-((R)-(1-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methylamino)ethyl)-3-(4-chlorophenyl)pyrido[2,3d]pyrimidin-4(3H)-one

: 1174540-21-6
(R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

Reference yield:

: 5345-47-1
2-aminopyridin-3-carboxylic acid

: 1174540-21-6
(R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

: 1262797-01-2
C₃₀H₂₇ClF₄N₄O₄S

Guidance literature:: Multi-step reaction with 9 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 21 h / Inert atmosphere; Large scale reaction

2.1: acetic acid / 66 h / 20 - 60 °C / Inert atmosphere; Large scale reaction

3.1: N-chloro-succinimide / acetic acid / 22 h / 40 - 53 °C / Large scale reaction

4.1: sodium azide / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere; Large scale reaction

5.1: tetrahydrofuran; water / 20 h / Inert atmosphere; Heating; Large scale reaction

6.1: hydrogenchloride / tetrahydrofuran; water / 15 h / 0 - 20 °C / Large scale reaction

7.1: water; isopropyl alcohol / Large scale reaction

8.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 0.5 h / -4 °C / Inert atmosphere; Large scale reaction

8.2: -5 °C

9.1: 1,1'-carbonyldiimidazole / acetonitrile / 0.33 h / Inert atmosphere; Large scale reaction

9.2: 21 h

With hydrogenchloride; N-chloro-succinimide; sodium azide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/jo102399a