1174540-28-3

Upstream product

• 50675-19-9 4-thianylcarbaldehyde 
• 106-47-8 4-chloro-aniline 
• 56329-05-6 2-amino-N-(4-chlorophenyl)nicotinamide 
• 1174540-24-9 2-(1-chloroethyl)-3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one 
• 1174540-23-8 3-(4-chlorophenyl)-2-ethylpyrido[2,3-d]pyrimidin-4(3H)-one 
• 1174540-26-1 2-(1-aminoethyl)-3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one 
• 1174540-25-0 C₁₅H₁₁ClN₆O 
• 494210-61-6 1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carbaldehyde 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 1174540-27-2 (+)-2-(1-(R)-aminoethyl)-3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one 

Downstream Products

• 1174540-21-6 (R)-2-(N-1-(3-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one)-N-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide 
• 1262797-01-2 C₃₀H₂₇ClF₄N₄O₄S 

Relevant academic research and scientific papers

Practical syntheses of a CXCR3 antagonist

Two new, reliable syntheses of a pyrido[2,3-d]- pyrimidine inhibitor of the CXCR3 receptor are described. A nine-step synthesis of the CXCR3 inhibitor (1) from 2-aminonicotinic acid was demonstrated on a multikilogram scale and incorporates a classic reso

CXCR3 ANTAGONISTS

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine recep