3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

Base Information

Chemical Name:3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester
CAS No.:1309100-66-0
Molecular Formula:C₃₉H₄₀N₄O₆
Molecular Weight:660.77
Hs Code.:

Synonyms:3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

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Chemical Property of 3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

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Technology Process of 3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

There total 4 articles about 3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂HF₃O₂*C₂₃H₂₂N₂O₃

: 13139-14-5
Boc-Trp-OH

: 1309100-66-0
3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2011.03.016

Reference yield:

: 904086-02-8
3'-[[(1,1-dimethylethoxy)carbonyl]amino][1,1'-biphenyl]-4-carboxylic acid

: 1309100-66-0
3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere

2: p-cresol / 1 h / Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With p-cresol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.016

Reference yield:

: 1309100-65-9
3'-[[(1,1-dimethylethoxy)carbonyl]amino]-[1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

: 1309100-66-0
3'-[N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophylamino][1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: p-cresol / 1 h / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With p-cresol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.016