3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine

Base Information

Chemical Name:3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine
CAS No.:336103-47-0
Molecular Formula:C₃₅H₃₂N₄O₅
Molecular Weight:588.663
Hs Code.:

Synonyms:3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine

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Chemical Property of 3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine

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Technology Process of 3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine

There total 8 articles about 3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: C₃₆H₃₄N₄O₅

: 336103-47-0
3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine

Guidance literature:: C₃₆H₃₄N₄O₅; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 4h;

With hydrogenchloride; water; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.03.016

Reference yield:

: C₂HF₃O₂*C₂₃H₂₂N₂O₃

: 336103-47-0
3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

2: p-cresol / 1 h / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 20 °C

With p-cresol; lithium hydroxide monohydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.016

Reference yield:

: 1309100-65-9
3'-[[(1,1-dimethylethoxy)carbonyl]amino]-[1,1'-biphenyl]-4-carbonyl-L-phenylalanine methyl ester

: 336103-47-0
3'-(N-acetyl-L-tryptophylamino)(1,1'-biphenyl)-4-carbonyl-L-phenylalanine

Guidance literature:: Multi-step reaction with 5 steps

1: p-cresol / 1 h / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3: p-cresol / 1 h / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

5: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 20 °C

With p-cresol; lithium hydroxide monohydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.016