6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1336905-20-4
Molecular Formula:C₂₁H₁₇BrF₃NO₃
Molecular Weight:468.27
Hs Code.:

Synonyms:6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Chemical Property of 6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Technology Process of 6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 4 articles about 6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 600-18-0
2-Oxobutyric acid

: 1336903-50-4
4-bromo-3-[(1-methylethyl)oxy]aniline

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 1336905-20-4
6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: 4-bromo-3-[(1-methylethyl)oxy]aniline; 3-Trifluoromethylbenzaldehyde; In ethanol; for 1h; Reflux;

2-Oxobutyric acid; In ethanol; at 20 ℃; for 19h; Reflux;

Reference yield:

: 77337-82-7
1-bromo-2-methoxy-4-nitrobenzene

: 1336905-20-4
6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide / water / 20 h / Reflux

2.1: potassium carbonate / acetonitrile / 2 h / Reflux

3.1: nickel(II) chloride tetrahydrate / acetonitrile / 0.08 h / 0 °C

3.2: 0.08 h / 0 °C

4.1: ethanol / 1 h / Reflux

4.2: 19 h / 20 °C / Reflux

With hydrogen bromide; potassium carbonate; nickel(II) chloride tetrahydrate; In ethanol; water; acetonitrile;

Reference yield:

: 52427-05-1
2-bromo-5-nitrophenol

: 1336905-20-4
6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 2 h / Reflux

2.1: nickel(II) chloride tetrahydrate / acetonitrile / 0.08 h / 0 °C

2.2: 0.08 h / 0 °C

3.1: ethanol / 1 h / Reflux

3.2: 19 h / 20 °C / Reflux

With potassium carbonate; nickel(II) chloride tetrahydrate; In ethanol; acetonitrile;