4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline

Base Information

• Chemical Name: 4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline
• CAS No.: 1376711-48-6
• Molecular Formula: C₂₈H₂₄N₂O₃S₂
• Molecular Weight: 500.642
• Mol file: 1376711-48-6.mol

Synonyms:4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline

Chemical Property of 4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline

There total 4 articles about 4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-bromo-4-methoxy-benzene (104-92-7) + 4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)aniline (1376711-46-4) → 4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline (1376711-48-6)

Guidance literature:

With tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 90 ℃; for 48h;

DOI:10.1016/j.dyepig.2012.02.014

Reference yield:

5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazol-4-ol (1376711-44-2) → 4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline (1376711-48-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

1.2: 24 h / 20 °C

2.1: hydrazine hydrate / methanol; water / 50 °C

3.1: tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 48 h / 90 °C

With tri-tert-butyl phosphine; potassium tert-butylate; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; water; dimethyl sulfoxide; toluene; 1.2: Williamson-type etherification / 3.1: Hartwige-Buchwald coupling;

DOI:10.1016/j.dyepig.2012.02.014

Reference yield:

thiophene-2-carbothioamide (20300-02-1) → 4-methoxy-N-(4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-N-(4-methoxyphenyl)aniline (1376711-48-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene / 24 h / Reflux

2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

2.2: 24 h / 20 °C

3.1: hydrazine hydrate / methanol; water / 50 °C

4.1: tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 48 h / 90 °C

With tri-tert-butyl phosphine; potassium tert-butylate; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; water; dimethyl sulfoxide; toluene; 1.1: Hantzsch cyclization / 2.2: Williamson-type etherification / 4.1: Hartwige-Buchwald coupling;

DOI:10.1016/j.dyepig.2012.02.014

upstream raw materials:

thiophene-2-carbothioamide

1-bromo-4-methoxy-benzene

4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)aniline

5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazol-4-ol

Downstream raw materials:

3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid

5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophene-2-carbaldehyde