3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid

Base Information

Chemical Name:3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid
CAS No.:1376711-54-4
Molecular Formula:C₃₂H₂₅N₃O₅S₂
Molecular Weight:595.7
Hs Code.:

Synonyms:3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid

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Chemical Property of 3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid

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Technology Process of 3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid

There total 7 articles about 3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1376711-51-1
5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophene-2-carbaldehyde

: 372-09-8
cyanoacetic acid

: 1376711-54-4
3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid

Guidance literature:: With piperidine; In acetonitrile; for 4h; Reflux; Inert atmosphere;
DOI:10.1016/j.dyepig.2012.02.014

Reference yield:

: 20300-02-1
thiophene-2-carbothioamide

: 1376711-54-4
3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 24 h / Reflux

2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

2.2: 24 h / 20 °C

3.1: hydrazine hydrate / methanol; water / 50 °C

4.1: tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 48 h / 90 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

5.2: 1.5 h / -78 - 20 °C

6.1: piperidine / acetonitrile / 4 h / Reflux; Inert atmosphere

With piperidine; n-butyllithium; tri-tert-butyl phosphine; potassium tert-butylate; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; water; dimethyl sulfoxide; toluene; acetonitrile; 1.1: Hantzsch cyclization / 2.2: Williamson-type etherification / 4.1: Hartwige-Buchwald coupling / 6.1: Knoevenagel condensation;
DOI:10.1016/j.dyepig.2012.02.014

Reference yield:

: 1376711-44-2
5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazol-4-ol

: 1376711-54-4
3-(5-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)-4-methoxythiazol-2-yl)thiophen-2-yl)-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

1.2: 24 h / 20 °C

2.1: hydrazine hydrate / methanol; water / 50 °C

3.1: tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 48 h / 90 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

4.2: 1.5 h / -78 - 20 °C

5.1: piperidine / acetonitrile / 4 h / Reflux; Inert atmosphere

With piperidine; n-butyllithium; tri-tert-butyl phosphine; potassium tert-butylate; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; water; dimethyl sulfoxide; toluene; acetonitrile; 1.2: Williamson-type etherification / 3.1: Hartwige-Buchwald coupling / 5.1: Knoevenagel condensation;
DOI:10.1016/j.dyepig.2012.02.014