2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Chemical Name:2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide
CAS No.:1616235-25-6
Molecular Formula:C₂₇H₂₃F₂N₇O₂
Molecular Weight:515.522
Hs Code.:

Synonyms:2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Chemical Property of 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Technology Process of 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

There total 10 articles about 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402-65-3
2-fluoropyridine-4-carboxylic acid

: 1616235-89-2
6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

: 1616235-25-6
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1616235-82-5
5-(3,6-dihydro-2H-pyran-4-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1616235-25-6
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium on activated charcoal; hydrogen / methanol / 8 h / Inert atmosphere

2: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

4: hydrogenchloride; methanol / 1,4-dioxane / 4 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; methanol; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; XPhos; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1616235-79-0
3,3-dibromo-1-(4-fluorophenyl)prop-2-en-1-one

: 1616235-25-6
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C / Molecular sieve

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / methanol / 8 h / Inert atmosphere

4: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

6: hydrogenchloride; methanol / 1,4-dioxane / 4 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;