6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

Base Information

Chemical Name:6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine
CAS No.:1616235-89-2
Molecular Formula:C₂₁H₂₁FN₆O
Molecular Weight:392.436
Hs Code.:

Synonyms:6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

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Chemical Property of 6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

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Technology Process of 6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

There total 9 articles about 6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616235-87-0
N-(6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

: 1616235-89-2
6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

Guidance literature:: With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

: 1616235-82-5
5-(3,6-dihydro-2H-pyran-4-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1616235-89-2
6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium on activated charcoal; hydrogen / methanol / 8 h / Inert atmosphere

2: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

4: hydrogenchloride; methanol / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; methanol; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; XPhos; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1616235-79-0
3,3-dibromo-1-(4-fluorophenyl)prop-2-en-1-one

: 1616235-89-2
6-(3-(4-fluorophenyl)-1-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C / Molecular sieve

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / methanol / 8 h / Inert atmosphere

4: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium phosphate / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

6: hydrogenchloride; methanol / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; triethylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;