9-Amino-2-hydroxyacridine

Base Information

• Chemical Name: 9-Amino-2-hydroxyacridine
• CAS No.: 7132-67-4
• Molecular Formula: C13H10N2O
• Molecular Weight: 0
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70221508
• Nikkaji Number: J55.117A
• Wikidata: Q83099305
• Mol file: 7132-67-4.mol

Synonyms:2-hydroxy-9-AA;9-amino-2-hydroxyacridine

Chemical Property of 9-Amino-2-hydroxyacridine

Chemical Property:

• Vapor Pressure: 5.07E-10mmHg at 25°C
• Boiling Point: 484.8°C at 760 mmHg
• Flash Point: 247°C
• PSA: 59.87000
• Density: 1.386g/cm³
• LogP: 2.60590
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 210.079312947
• Heavy Atom Count: 16
• Complexity: 258

Purity/Quality:

99% ^*data from raw suppliers

9-AMINO-2-HYDROXYACRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=C3C=C(C=CC3=N2)O)N

Technology Process of 9-Amino-2-hydroxyacridine

There total 14 articles about 9-Amino-2-hydroxyacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.9%

2-methoxy-9-amino-acridine (3407-99-6) → 9-amino-acridin-2-ol (7132-67-4)

Guidance literature:

With water; hydrogen bromide; for 3h; Heating;

DOI:10.1271/bbb.60.714

Reference yield: 54.0%

2-hydroxy-9-methoxycarbonylaminoacridine (202657-84-9) → 9-amino-acridin-2-ol (7132-67-4)

Guidance literature:

With potassium hydroxide; for 1h; Heating;

DOI:10.1002/jhet.5570340604

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → 9-amino-acridin-2-ol (7132-67-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 62 percent / NH₃ (gas) / ethane-1,2-diol / 1 h / 150 - 160 °C

2: 87 percent / 30percent aq. H₂O₂ / acetic acid / 5 h / 80 °C

3: 78 percent / 1 h / 90 °C

4: 69 percent / Br₂, MeOH / 0.33 h / Heating

5: 92 percent / 10percent aq. HCl / 1 h / 40 °C

6: 54 percent / 20percent aq. KOH / 1 h / Heating

With hydrogenchloride; methanol; potassium hydroxide; ammonia; dihydrogen peroxide; bromine; In ethylene glycol; acetic acid;

DOI:10.1002/jhet.5570340604

upstream raw materials:

2-methoxy-9-amino-acridine

aminacrine

2-hydroxy-9-methoxycarbonylaminoacridine

cyclohexanedione monoethylene ketal