perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate

Base Information

Chemical Name:perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate
CAS No.:1375457-32-1
Molecular Formula:C₂₁H₁₄F₅N₅O₃S
Molecular Weight:511.432
Hs Code.:

Synonyms:perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate

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Technology Process of perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate

There total 4 articles about perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 928656-94-4
pentafluorophenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonate

: 1375457-23-0
4-chloro-5-methyl-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine

: 1375457-32-1
perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate

Guidance literature:: With borax; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1375457-32-1
perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

3: borax / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; ethanol / 0.25 h / 120 °C / Microwave irradiation

With borax; sodium acetate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 848649-38-7
4-bromobenzenesulfonic acid pentafluorophenyl ester

: 1375457-32-1
perfluorophenyl 4-(5-methyl-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)benzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

2: borax / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; ethanol / 0.25 h / 120 °C / Microwave irradiation

With borax; sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol;