1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone

Base Information

• Chemical Name: 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone
• CAS No.: 1339838-72-0
• Molecular Formula: C₁₀H₈F₄O
• Molecular Weight: 220.167
• Mol file: 1339838-72-0.mol

Synonyms:1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone

Chemical Property of 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone

There total 14 articles about 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2,2-difluorocyclopropyl)(4-fluorophenyl)methanone (1186338-51-1) → 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone (1339838-72-0)

Guidance literature:

With boron trifluoride diethyl etherate; In chloroform; at 60 ℃;

DOI:10.1039/c3cc47879c

Reference yield: 84.0%

(Z)-4-(4-fluorophenyl)-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonate → 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone (1339838-72-0)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at -40 - 80 ℃; for 8h;

DOI:10.1002/ejoc.201801025

Reference yield: 84.0%

→ 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone (1339838-72-0)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at -40 - 80 ℃; for 8h; Inert atmosphere; Schlenk technique;

upstream raw materials:

1-(4-fluorophenyl)-2-propen-1-one

(2,2-difluorocyclopropyl)(4-fluorophenyl)methanone

1-(4-fluorophenyl)ethanone

(E)-trimethyl(3,3,3-trifluoroprop-1-en-1-yl)silane

Refernces

• 1、 -. "Preparation method of 1-aryl-4,4,4-trifluoro-1-butanone compound". Paragraph 0047; 0066-0068. . Retrieved 2018/11/10.
• 2、 Zhou, Yuhan,Zhang, Chunxia,Zhao, Yilong,Li, Dong,Zhao, Jinfeng,Wang, Zhaotian,Qu, Jingping. "Base-Promoted Double-Bond-Migration/Hydrolysis/Isomerization of 4-Aryl-1,1,1-trifluorobut-2-en-2-yl Trifluoromethanesulfonates: A Metal-Free Approach to β-Trifluoromethyl Ketones". . p. 6217 - 6222. Retrieved 2018/11/23.