1186338-51-1

Basic information

• Product Name: (2,2-difluorocyclopropyl)(4-fluorophenyl)methanone
• Synonyms: (2,2-difluorocyclopropyl)(4-fluorophenyl)methanone
• CAS NO: 1186338-51-1
• Molecular Weight: 200.16
• Mol File: 1186338-51-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2,2-difluorocyclopropyl)(4-fluorophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2,2-difluorocyclopropyl)(4-fluorophenyl)methanone(1186338-51-1)
• EPA Substance Registry System: (2,2-difluorocyclopropyl)(4-fluorophenyl)methanone(1186338-51-1)

Safety Data

• Hazardous Substances Data: 1186338-51-1(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 51594-59-3 1-(4-fluorophenyl)-2-propen-1-one 
• 120801-75-4 trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate 
• 1186338-32-8 C₁₂H₉F₃O₂ 

Downstream Products

• 1461634-34-3 (5-fluoro-2-methyl-1H-pyrrol-3-yl)(4-fluorophenyl)methanone 
• 1339838-72-0 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone 
• 1529771-21-8 4-chloro-4,4-difluoro-1-(4-fluorophenyl)butan-1-one 
• 1529771-31-0 4-bromo-4,4-difluoro-1-(4-fluorophenyl)butan-1-one 

Relevant articles and documents

Boron-trihalide-promoted regioselective ring-opening reactions of gem-difluorocyclopropyl ketones

Boron trihalide-promoted ring-opening reactions of gem-difluorocyclopropyl ketones to give the corresponding β-trifluoromethyl ketones and β-halodifluoromethyl ketones were described. It was found that boron trihalides act as both Lewis acids and nucleophiles and the proximal bond prefers to cleave in this transformation.

Reaction of difluorocarbene with propargyl esters and efficient synthesis of difluorocyclopropyl ketones

Difluorocarbene generated from FSO2CF2CO2SiMe3 (TFDA) at 120 °C could reacted with terminal alkynes having an ester group at the α position to the triple bond. Difluorocyclopropenes were further converted to difluorocyclopropyl ketones under alkaline condition. Mechanism for the conversion was studied.