6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester

Base Information

Chemical Name:6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester
CAS No.:154377-73-8
Molecular Formula:C₂₁H₂₂INO₄
Molecular Weight:479.314
Hs Code.:

Synonyms:6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester

Suppliers and Price of 6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester

There total 5 articles about 6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 6-(4-{4-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-iodo-phenoxymethyl}-pyridin-3-yl)-hex-5-ynoic acid methyl ester

: 154377-73-8
6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)61429-6

Reference yield:

: 77758-51-1
methyl hex-5-ynoate

: 154377-73-8
6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / (Ph₃P)2PdCl₂, CuI, Et₃N / acetonitrile / 1.5 h / Heating

2: 100 percent / NaBH₄ / methanol / -20 °C

3: 57 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

4: 90 percent / Bu₄NF / tetrahydrofuran

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4039(00)61429-6

Reference yield:

: 70201-43-3
3-bromo-pyridine-4-carbaldehyde

: 154377-73-8
6-{4-[4-(2-Hydroxy-ethyl)-2-iodo-phenoxymethyl]-pyridin-3-yl}-hex-5-ynoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / (Ph₃P)2PdCl₂, CuI, Et₃N / acetonitrile / 1.5 h / Heating

2: 100 percent / NaBH₄ / methanol / -20 °C

3: 57 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

4: 90 percent / Bu₄NF / tetrahydrofuran

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4039(00)61429-6