dimethyl(2-p-tolyl-2-hydroxyethyl)amine cyanoborane

Base Information

Chemical Name:dimethyl(2-p-tolyl-2-hydroxyethyl)amine cyanoborane
CAS No.:705292-56-4
Molecular Formula:C₁₂H₁₉BN₂O
Molecular Weight:218.107
Hs Code.:

Synonyms:dimethyl(2-p-tolyl-2-hydroxyethyl)amine cyanoborane

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Chemical Property of dimethyl(2-p-tolyl-2-hydroxyethyl)amine cyanoborane

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Technology Process of dimethyl(2-p-tolyl-2-hydroxyethyl)amine cyanoborane

There total 1 articles about dimethyl(2-p-tolyl-2-hydroxyethyl)amine cyanoborane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 30353-61-8
trimethylamine-cyanoborane

: 104-87-0
4-methyl-benzaldehyde

: 705292-56-4
dimethyl(2-p-tolyl-2-hydroxyethyl)amine cyanoborane

Guidance literature:: With sec.-butyllithium; In tetrahydrofuran; cyclohexane; (N2); soln. of s-BuLi (1.5 equiv.) in cyclohexane was added dropwise tosoln. of Me3NBH2CN in THF at -78°C; mixt. warmed to room temp. o ver 1 h; recooled to -78°C; electrophile added; after 5 min cooling bath removed; stirred for 0.5 h; aq. NaHCO3 added; org. layer septd.; washed (brine); dried (Na2SO4); filtered; concd. (vac.); ether added; stirred for 3 h; aq. NaHCO3 added; filtered; ether layer dried (Na2SO4); filtered; concd. (vac.); CH2Cl2 added; washed (H2O); extd.; elem. anal.;
DOI:10.1021/om049816p