3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester

Base Information

Chemical Name:3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester
CAS No.:343255-44-7
Molecular Formula:C₁₉H₂₃NO₅
Molecular Weight:345.395
Hs Code.:

Synonyms:3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester

Suppliers and Price of 3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester

There total 4 articles about 3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 343255-43-6
[3-(3,4-dimethoxyphenyl)-but-3-enyl]furan-2-yl-carbamic acid ethyl ester

: 343255-44-7
3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester

Guidance literature:: In toluene; at 155 ℃; for 20h;
DOI:10.1021/jo010020z

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 343255-44-7
3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / AlCl₃ / CS₂ / 3 h / Heating

2: 80 percent / tetrahydrofuran; toluene / -40 - 20 °C

3: 55 percent / KOH; K₂CO₃; Bu₄NHSO₄ / benzene / 40 h / 50 °C

4: 78 percent / toluene / 20 h / 155 °C

With potassium hydroxide; aluminium trichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In tetrahydrofuran; carbon disulfide; toluene; benzene;
DOI:10.1021/jo010020z

Reference yield:

: 105174-63-8
3-bromo-1-(3,4-dimethoxyphenyl)propan-1-one

: 343255-44-7
3a-(3,4-dimethoxyphenyl)-5-oxo-2,3,3a,4,5,6-hexahydroindole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / tetrahydrofuran; toluene / -40 - 20 °C

2: 55 percent / KOH; K₂CO₃; Bu₄NHSO₄ / benzene / 40 h / 50 °C

3: 78 percent / toluene / 20 h / 155 °C

With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In tetrahydrofuran; toluene; benzene;
DOI:10.1021/jo010020z