Methoxsalen

Base Information Edit

Chemical Name:Methoxsalen
CAS No.:298-81-7
Deprecated CAS:12692-94-3
Molecular Formula:C12H8O4
Molecular Weight:216.193
Hs Code.:29322090
European Community (EC) Number:206-066-9
NSC Number:757114,45923
UN Number:1759
UNII:U4VJ29L7BQ
DSSTox Substance ID:DTXSID8020830
Nikkaji Number:J2.983A
Wikipedia:Methoxsalen
Wikidata:Q408570
NCI Thesaurus Code:C643
RXCUI:6854
Pharos Ligand ID:X7VNVLGFGBAW
Metabolomics Workbench ID:42889
ChEMBL ID:CHEMBL416
Mol file:298-81-7.mol

Synonyms:8 Methoxypsoralen;8 MOP;8-Methoxypsoralen;8-MOP;8MOP;Ammoidin;Deltasoralen;Dermox;Geroxalen;Méladinine;Meladinina;Meladinine;Meloxine;Methoxa Dome;Methoxa-Dome;Methoxsalen;Oxsoralen;Oxsoralen Ultra;Oxsoralen-Ultra;Puvalen;Ultramop;Xanthotoxin

Suppliers and Price of Methoxsalen

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Xanthotoxin
20mg
$ 297.00

TRC
8-MethoxyPsoralen
50mg
$ 65.00

TCI Chemical
Xanthotoxin >98.0%(GC)
100mg
$ 14.00

TCI Chemical
Xanthotoxin >98.0%(GC)
1g
$ 43.00

Sigma-Aldrich
Xanthotoxin analytical standard
50mg
$ 102.00

Sigma-Aldrich
8-Methoxypsoralen analytical standard
5g
$ 206.00

Sigma-Aldrich
8-Methoxypsoralen analytical standard
1g
$ 43.10

Sigma-Aldrich
Methoxsalen United States Pharmacopeia (USP) Reference Standard
200mg
$ 366.00

Medical Isotopes, Inc.
Methoxsalen
10 mg
$ 890.00

Labseeker
8-METHOXYPSORALEN 99
1kg
$ 7170.00

Total 153 raw suppliers

Chemical Property of Methoxsalen Edit

Chemical Property:

Appearance/Colour:Crystalline Solid
Vapor Pressure:4.33E-07mmHg at 25°C
Melting Point:148-150 °C(lit.)
Refractive Index:1.635
Boiling Point:414.795 °C at 760 mmHg
Flash Point:204.661 °C
PSA：52.58000
Density:1.368 g/cm³
LogP:2.54780
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:H2O: slightly soluble
Water Solubility.:PRACTICALLY INSOLUBLE
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:216.04225873
Heavy Atom Count:16
Complexity:325
Transport DOT Label:Corrosive

Purity/Quality:

more than 98% ^*data from raw suppliers

Xanthotoxin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, T
Hazard Codes:Xn,T
Statements: 22-43-46-45-34
Safety Statements: 36/37-53-45-36/37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Other Classes -> Other Organic Compounds
Canonical SMILES:COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
Recent ClinicalTrials:Extracorporeal Photopheresis in Sezary Syndrome
Recent EU Clinical Trials:Phase II multicenter study of extracorporeal photopheresis with UvadexTM plus standard steroid treatment for high risk acute Graft-versus-Host Disease
Description 8-methoxypsoralen (also known as methoxsalen) is a naturally occurring furocoumarin compound existing in several species of plants such as Psoralea corylifolia. It is a photoactive substance that can form DNA adducts upon UVA irradiation. It is a drug used for the treatment of psoriasis, eczema, vitiligo, and some kinds of cutaneous lymphomas associated with the exposure of skin to the UVA or light from lamps or sunlight. Its mechanism of action is through inhibiting the synthesis of the deoxyribonucleic acid (DNA). After the activation, it can preferentially bind to the guanine and cytosine molecules of DNA, further leading to the cross-linking of DNA, thus inhibiting the DNA synthesis. It can further inhibit the RNA and protein synthesis at high concentration. It is extracted from Ammi majus. 8-Methoxypsoralen (8-MOP) and other psoralens are naturally found in plants, including common fruit and vegetable crops.
Uses 8-Methoxypsoralen, is used in Photochemotherapy (methoxsalen with long wave ultraviolet radiation) is indicated for the repigmentation of idiopathic vitiligo. It is also used in Photopheresis (methoxsalen with long wave ultraviolet radiation of white blood cells) is indicated for use with the UVAR* System in the palliative treatment of the skin manifestations of cutaneous T-cell lymphoma. antipsoriatic, pigmentation agent Naturally occurring analog of Psoralen (P839800). Use in treatment of psoriasis and mycosis fungoides. For the treatment of psoriasis and vitiligo A potent suicide inhibitor of cytochrome P-450. Naturally occurring analog of psoralen. Use in treatment of psoriasis and mycosis fungoides
Indications Methoxsalen has effects similar to those of trioxsalen. Methoxsalen is superior to trioxsalen in producing erythema and tanning and is the drug used in PUVA therapy. Methoxsalen is also available as a 1% lotion.
Therapeutic Function Dermal pigmentation enhancer

Technology Process of Methoxsalen

There total 48 articles about Methoxsalen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%