1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine

Base Information

Chemical Name:1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine
CAS No.:686777-01-5
Molecular Formula:C₃₇H₆₂N₆O₉
Molecular Weight:734.934
Hs Code.:

Synonyms:1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine

Suppliers and Price of 1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine

There total 5 articles about 1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

: 686777-00-4
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-α-carbobenzyloxy-p-bromoacetylamide-L-phenylalanine benzyl ester

: 686777-01-5
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine

Guidance literature:: With hydrogen; palladium on activated charcoal; In isopropyl alcohol; for 72h; under 2068.59 Torr;
DOI:10.1002/chem.200305389

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 686777-01-5
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95.6 percent / aq. Na₂CO₃ / dioxane / 20 °C

2.1: 95.1 percent / (i-Pr)2NEt / acetonitrile / 48 h / 20 °C

3.1: 90.9 percent / zinc / ethanol; acetic acid / 2 h / 65 °C

4.1: 96.7 percent / (i-Pr)2NEt / CH₂Cl₂ / -97 - 20 °C

5.1: K₂CO₃ / acetonitrile / 0.25 h / 60 °C

5.2: 100 percent / acetonitrile / 72 h / 60 °C

6.1: 99.3 percent / H₂ / Pd/C / propan-2-ol / 72 h / 2068.59 Torr

With hydrogen; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; acetic acid; isopropyl alcohol; acetonitrile;
DOI:10.1002/chem.200305389

Reference yield:

: 686776-98-7
N-α-carbobenzyloxy-p-amino-L-phenylalanine benzyl ester

: 686777-01-5
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-p-acetylamide-L-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96.7 percent / (i-Pr)2NEt / CH₂Cl₂ / -97 - 20 °C

2.1: K₂CO₃ / acetonitrile / 0.25 h / 60 °C

2.2: 100 percent / acetonitrile / 72 h / 60 °C

3.1: 99.3 percent / H₂ / Pd/C / propan-2-ol / 72 h / 2068.59 Torr

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1002/chem.200305389