1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-oxo-2-[[4-[(2S)-3-oxo-3-(phenylmethoxy)-2-[[(phenylmethoxy)carb onyl]amino]propyl]phenyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester

Base Information

Chemical Name:1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-oxo-2-[[4-[(2S)-3-oxo-3-(phenylmethoxy)-2-[[(phenylmethoxy)carb onyl]amino]propyl]phenyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester
CAS No.:686777-00-4
Molecular Formula:C52H74N6O11
Molecular Weight:959.193
Hs Code.:

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid,
10-[2-oxo-2-[[4-[(2S)-3-oxo-3-(phenylmethoxy)-2-[[(phenylmethoxy)carb
onyl]amino]propyl]phenyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester

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Chemical Property of 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-oxo-2-[[4-[(2S)-3-oxo-3-(phenylmethoxy)-2-[[(phenylmethoxy)carb onyl]amino]propyl]phenyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester

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Technology Process of 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-oxo-2-[[4-[(2S)-3-oxo-3-(phenylmethoxy)-2-[[(phenylmethoxy)carb onyl]amino]propyl]phenyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester

There total 4 articles about 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-oxo-2-[[4-[(2S)-3-oxo-3-(phenylmethoxy)-2-[[(phenylmethoxy)carb onyl]amino]propyl]phenyl]amino]ethyl]-, tris(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 122555-91-3
1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

: 686776-99-8
N-α-carbobenzyloxy-p-bromoacetylamide-L-phenylalanine benzyl ester

: 686777-00-4
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-α-carbobenzyloxy-p-bromoacetylamide-L-phenylalanine benzyl ester

Guidance literature:: 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane; With potassium carbonate; In acetonitrile; at 60 ℃; for 0.25h;

N-α-carbobenzyloxy-p-bromoacetylamide-L-phenylalanine benzyl ester; In acetonitrile; at 60 ℃; for 72h;
DOI:10.1002/chem.200305389

Reference yield:

: 100-39-0
benzyl bromide

: 686777-00-4
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-α-carbobenzyloxy-p-bromoacetylamide-L-phenylalanine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95.1 percent / (i-Pr)2NEt / acetonitrile / 48 h / 20 °C

2.1: 90.9 percent / zinc / ethanol; acetic acid / 2 h / 65 °C

3.1: 96.7 percent / (i-Pr)2NEt / CH₂Cl₂ / -97 - 20 °C

4.1: K₂CO₃ / acetonitrile / 0.25 h / 60 °C

4.2: 100 percent / acetonitrile / 72 h / 60 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1002/chem.200305389

Reference yield:

: 17224-90-7
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid

: 686777-00-4
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-α-carbobenzyloxy-p-bromoacetylamide-L-phenylalanine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95.1 percent / (i-Pr)2NEt / acetonitrile / 48 h / 20 °C

2.1: 90.9 percent / zinc / ethanol; acetic acid / 2 h / 65 °C

3.1: 96.7 percent / (i-Pr)2NEt / CH₂Cl₂ / -97 - 20 °C

4.1: K₂CO₃ / acetonitrile / 0.25 h / 60 °C

4.2: 100 percent / acetonitrile / 72 h / 60 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1002/chem.200305389