4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one

Base Information

Chemical Name:4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one
CAS No.:1313365-97-7
Molecular Formula:C₁₉H₂₈IN₃O
Molecular Weight:441.355
Hs Code.:

Synonyms:4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one

Suppliers and Price of 4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one

There total 10 articles about 4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1313365-98-8
[[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-amino]-acetic acid methyl ester

: 1313365-97-7
4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one

Guidance literature:: [[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-amino]-acetic acid methyl ester; With hydrogenchloride; In 1,4-dioxane; water; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

With triethylamine; In 1,4-dioxane; methanol; at 0 - 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.5b00810

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 1313365-97-7
4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 20 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; water / 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.2: 0 °C / pH 9

4.1: potassium carbonate / N,N-dimethyl-formamide / 4.5 h / -10 - 10 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

5.2: pH 8

6.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C

6.2: 0 - 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1313365-94-4
(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexylamino)-acetic acid methyl ester

: 1313365-97-7
4-(4-{[(4-iodo-phenyl)-methyl-amino]-methyl}-trans-cyclohexyl)-1-methyl-piperazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

1.2: pH 8

2.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C

2.2: 0 - 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; In 1,4-dioxane; dichloromethane;