methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate

Base Information

Chemical Name:methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate
CAS No.:1072003-03-2
Molecular Formula:C₂₃H₁₉ClN₂O₄
Molecular Weight:422.868
Hs Code.:

Synonyms:methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate

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Chemical Property of methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate

Chemical Property:

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Technology Process of methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate

There total 4 articles about methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1072003-02-1
[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methanol

: 19438-10-9
methyl 3-hydroxybenzoate

: 1072003-03-2
methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In dichloromethane; for 3h;

Reference yield:

: 1072002-99-3
tert-butyl [5-(3-chlorophenoxy)-2-nitrophenyl]methylcarbamate

: 1072003-03-2
methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / ethanol; water / 5 h / Reflux

2: hydrogenchloride / 1,4-dioxane; water / 2 h / Reflux

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 10 h / Inert atmosphere

With hydrogenchloride; tributylphosphine; iron; ammonium chloride; 1,1'-azodicarbonyl-dipiperidine; In 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmc.2018.09.006

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1072003-03-2
methyl 3-{[6-(3-chlorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 10 h / 80 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / 5 h / Reflux

3: hydrogenchloride / 1,4-dioxane; water / 2 h / Reflux

4: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / 10 h / Inert atmosphere

With hydrogenchloride; tributylphosphine; iron; sodium hydride; ammonium chloride; 1,1'-azodicarbonyl-dipiperidine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.09.006