4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

Base Information

Chemical Name:4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
CAS No.:1093861-36-9
Molecular Formula:C₂₇H₁₇F₁₂N₃O₃
Molecular Weight:659.431
Hs Code.:

4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

Synonyms:4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

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Chemical Property of 4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

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Technology Process of 4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

There total 5 articles about 4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 753-90-2
trifluoroethylamine

: 1092708-58-1
N-[[4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenyl]carbonyl]glycine

: 1093861-36-9
4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

Guidance literature:: With PS-carbodiimide; In dichloromethane; at 20 ℃;

Reference yield:

: 1093862-53-3
N-[[4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenyl]carbonyl]glycine methyl ester

: 1093861-36-9
4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran / 1 h / 20 °C

2: PS-carbodiimide / dichloromethane / 20 °C

With lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1093862-52-2
5-[3,5-bis(trifluoromethyl)phenyl]-3-(4-bromo-1-naphthalenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole

: 1093861-36-9
4-[5-(3,5-bis(trifluoromethyl)phenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 70 °C

2: lithium hydroxide / water; tetrahydrofuran / 1 h / 20 °C

3: PS-carbodiimide / dichloromethane / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;