N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Base Information

Chemical Name:N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate
CAS No.:1344707-58-9
Molecular Formula:C₂HF₃O₂*C₂₅H₁₉F₃N₆O₄
Molecular Weight:638.483
Hs Code.:

Synonyms:N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Suppliers and Price of N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

There total 11 articles about N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.4%

: 1344482-68-3
(S)-1-(1H-imidazol-2-yl)ethanamine

: 2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid

: 76-05-1
trifluoroacetic acid

: 1344707-58-9
N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Guidance literature:: (S)-1-(1H-imidazol-2-yl)ethanamine; 2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; for 1h;

trifluoroacetic acid; In methanol; water;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1344707-58-9
N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

3.1: Jones reagent / acetone / 20 °C

4.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

7.1: carbon dioxide / methanol / 45 °C / Resolution of racemate

8.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h

8.2: PHENOMENEX_.(R). Luna 5u

With 4-methyl-morpholine; pyridine; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; carbon dioxide; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1344707-58-9
N-((S)-1-(1H-imidazol-2-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

2.1: Jones reagent / acetone / 20 °C

3.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

6.1: carbon dioxide / methanol / 45 °C / Resolution of racemate

7.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h

7.2: PHENOMENEX_.(R). Luna 5u

With 4-methyl-morpholine; pyridine; Jones reagent; trifluoro-[1,3,5]triazine; carbon dioxide; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;